Download Retro Reason Studio 32 bit from here:
torrent or
archive.org
For several years I ran Reason 5.0.1 on Linux under WINE, but the experience was always somewhat subpar. Aside from latency and stability troubles, things I was able to resolve, two bugs in WINE were exceedingly annoying to me. Examples: Not being able to use the pulldown menu in Reason. Vertical labels on devices not rendering properly.
These bugs I reported to the community, and I set a bounty for anyone able to fix them. However, they were not to be fixed. So I resorted to building a minimalist virtual machine that can be run under virt-manager/qemu-kvm under Linux to be able to make music more comfortably.
Reason 5 is now considered abandonware. This means you can use it for free. This 32 bit virtual machine is built on top of the Tiny7 windows build by [eXPerience]. I have further cut down this minimalist system and "frankensteined" it into a lean setup for production with a Wasapi ASIO flexible audio setup. I've been making music with this myself and it works a charm. Just make sure to tweak your virtual machine to run as close to your hardware as possible, and you should get native performance with most multiple-core CPU hardware.
As time progresses I hope to add useful things to this page, like tools I have made for a better Reason 5 experience. Please also follow my videos for more updates on this!